TITLE

Fondaparinux was not inferior to unfractionated heparin for symptomatic pulmonary embolism

PUB. DATE
May 2004
SOURCE
ACP Journal Club;May/Jun2004, Vol. 140 Issue 3, p68
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This article presents a study, which states that in patients with symptomatic pulmonary embolism (PE), fondaparinux is noninferior to unfractionated heparin (UFH). 2213 patients, who had acute symptomatic PE and required antithrombotic therapy, were taken for the study. Exclusion criteria were receipt of low-molecular-weight heparin or oral anticoagulants greater than 24 hours; need for thrombolysis, embolectomy, or a vena cava filter; contraindication to anticoagulant therapy; serum creatinine level greater than 177. Composite endpoint of symptomatic recurrent venous thromboembolism, with 95% power to reject an absolute recurrence rate of 3.5% higher with fondaparinux than UFH.
ACCESSION #
13221837

 

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