1-day quadruple therapy was not inferior to 7-day triple therapy for eradication of Helicobacter pylori infection in dyspepsia: COMMENTARY

Mukherjee, Debjani; Schwartz, Mark D.
May 2004
ACP Journal Club;May/Jun2004, Vol. 140 Issue 3, p66
Academic Journal
Dyspepsia is endemic and chronic. Most patients who are evaluated are diagnosed with nonulcer, or functional, dyspepsia. Systematic reviews support a modest benefit of H. pylori eradication in such patients, with perhaps 1 cure for every 15 patients treated. A Cochrane review concluded that the Helicobacter pylori test-and-treat approach may be less expensive and just as effective as endoscopy-based management in younger patients without alarm symptoms, showed similar efficacy of 1-day and standard 7-day treatment in achieving H. pylori eradication. Although dyspepsia symptoms improved, few patients had complete relief. If reproducible, a single-day course would likely have great advantages in cost, convenience, and adverse effects.


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