Buprenorphine alone or in combination with naloxone reduced the use of and craving for opiates in opiate addiction

May 2004
ACP Journal Club;May/Jun2004, Vol. 140 Issue 3, p65
Academic Journal
This article presents a study to find out whether buprenorphine alone or in combination with naloxone, is more effective than placebo for reducing the use of opiates and the craving for opiates in opiate-addicted outpatients. 326 patients defined as opiate dependent who were 18 to 59 years of age and were seeking opiate-substitution pharmacotherapy, were taken for the study. 110 patients were allocated to daily, office-based combination treatment with 16-mg sublingual buprenorphine plus 4-mg naloxone for 4 weeks; buprenorphine was administered alone on day 1 and day 2 to minimize the risk for naloxone-induced opiate withdrawal. 106 patients were allocated to buprenorphine alone; 8 mg on day 1, and 16 mg thereafter.


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