Structured interruption of treatment hastened disease progression in multidrug-resistant HIV

May 2004
ACP Journal Club;May/Jun2004, Vol. 140 Issue 3, p64
Academic Journal
This article presents a study, to determine whether structured treatment interruption (STI) more effective than an immediate change in drug regimen for delaying disease progression or death in patients with multidrug-resistant HIV infection. 270 patients who were 13 years of age, had an HIV RNA level greater than 5000 copies/mL, and genotypic evidence of multidrug-resistant virus, were taken for the study. Patients were allocated to STI, followed by the initiation of an optimized antiretroviral regimen or immediate initiation of an optimized antiretroviral regimen.


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