TITLE

Structured interruption of treatment hastened disease progression in multidrug-resistant HIV

PUB. DATE
May 2004
SOURCE
ACP Journal Club;May/Jun2004, Vol. 140 Issue 3, p64
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This article presents a study, to determine whether structured treatment interruption (STI) more effective than an immediate change in drug regimen for delaying disease progression or death in patients with multidrug-resistant HIV infection. 270 patients who were 13 years of age, had an HIV RNA level greater than 5000 copies/mL, and genotypic evidence of multidrug-resistant virus, were taken for the study. Patients were allocated to STI, followed by the initiation of an optimized antiretroviral regimen or immediate initiation of an optimized antiretroviral regimen.
ACCESSION #
13221829

 

Related Articles

  • Structured interruption of treatment hastened disease progression in multidrug-resistant HIV: COMMENTARY. Walmsley, Sharon // ACP Journal Club;May/Jun2004, Vol. 140 Issue 3, p64 

    Structured treatment interruption (STI) is being evaluated as a strategy in many stages of HIV infection. A retrospective cohort study suggested that an STI before the initiation of salvage therapy could result in improved viral load and CD4 count responses. A series of controlled trials tested...

  • Results of Antiretroviral Treatment Interruption and Intensification in Advanced Multi-Drug Resistant HIV Infection from the OPTIMA Trial. Holodniy, Mark; Brown, Sheldon T.; Cameron, D. William; Kyriakides, Tassos C.; Angus, Brian; Babiker, Abdel; Singer, Joel; Owens, Douglas K.; Anis, Aslam; Goodall, Ruth; Hudson, Fleur; Piaseczny, Mirek; Russo, John; Schechter, Martin; Deyton, Lawrence; Darbyshire, Janet // PLoS ONE;2011, Vol. 6 Issue 3, p1 

    Background: Guidance is needed on best medical management for advanced HIV disease with multidrug resistance (MDR) and limited retreatment options. We assessed two novel antiretroviral (ARV) treatment approaches in this setting. Methods and Findings: We conducted a 2×2 factorial randomized...

  • The Spectrum projection package: improvements in estimating mortality, ART needs, PMTCT impact and uncertainty bounds. Stover, J; Johnson, P; Zaba, B; Zwahlen, M; Dabis, F; Ekpini, H E // Sexually Transmitted Infections;Aug2008 Supplement 1, Vol. 84 Issue S1, pi24 

    Background: The approach to national and global estimates of HIV/AIDS used by UNAIDS starts with estimates of adult HIV prevalence prepared from surveillance data using either the Estimation and Projection Package (EPP) or the Workbook. Time trends of prevalence are transferred to Spectrum to...

  • Uptake of HIV testing and treatment in an isolated population with access to free and universal healthcare. Gillieatt, Sue J.; Mallal, Simon A.; Gillieatt, S J; Mallal, S A // International Journal of STD & AIDS;May2000, Vol. 11 Issue 5, p303 

    This Western Australian study analysed clinical information from 344 people with AIDS, and experiential data from a sample of 36 people with AIDS to investigate 2 relevant issues: the timing of HIV testing and uptake and experiences of HIV drug treatment. We found that the proportion of people...

  • Risco cardiovascular em doentes infectados por Vírus da Imunodeficiência Humana. Valadas, E.; Sousa, S.; Antunes, F. // RPDI - Revista Portuguesa de Doenças Infecciosas;jan-abr2009, Vol. 5 Issue 1, p07 

    Introduction: Human immunodeficiency virus (HIV) infection, as well as some antiretroviral drugs, has been described to aggravate classical risk factors for cardiovascular disease. Objective: To quantify the cardiovascular risk (CVR) in HIV infected individuals, and to determine the prevalence...

  • A Prognostic Model for Estimating the Time to Virologic Failure in HIV-1 Infected Patients Undergoing a New Combination Antiretroviral Therapy Regimen. Prosperi, Mattia C. F.; Giambenedetto, Simona Di; Fanti, Iuri; Meini, Genny; Bruzzone, Bianca; Callegaro, Annapaola; Penco, Giovanni; Bagnarelli, Patrizia; Micheli, Valeria; Paolini, Elisabetta; Di Biagio, Antonio; Ghisetti, Valeria; Pietro, Massimo Di; Zazzi, Maurizio; De Luca, Andrea // BMC Medical Informatics & Decision Making;2011, Vol. 11 Issue 1, p40 

    Background: HIV-1 genotypic susceptibility scores (GSSs) were proven to be significant prognostic factors of fixed time-point virologic outcomes after combination antiretroviral therapy (cART) switch/initiation. However, their relative-hazard for the time to virologic failure has not been...

  • HIV Treatment Beliefs and Sexual Transmission Risk Behaviors among HIV Positive Men and Women. Kalichman, Seth C.; Eaton, Lisa; Cain, Demetria; Cherry, Charsey; Pope, Howard; Kalichman, Moira // Journal of Behavioral Medicine;Oct2006, Vol. 29 Issue 5, p401 

    People are living longer and healthier with HIV infection because of successful combination antiretroviral therapies. HIV treatment beliefs are often associated with sexual practices among people living with HIV/AIDS but these associations may depend on the HIV status of sex partners. In a...

  • Beyond Core Indicators of Retention in HIV Care: Missed Clinic Visits Are Independently Associated With All-Cause Mortality. Mugavero, Michael J.; Westfall, Andrew O.; Cole, Stephen R.; Geng, Elvin H.; Crane, Heidi M.; Kitahata, Mari M.; Mathews, W. Christopher; Napravnik, Sonia; Eron, Joseph J.; Moore, Richard D.; Keruly, Jeanne C.; Mayer, Kenneth H.; Giordano, Thomas P.; Raper, James L. // Clinical Infectious Diseases;Nov2014, Vol. 59 Issue 10, p1471 

    Missed HIV care visits have independent prognostic value for clinical events beyond core indicators of retention in care. As this information is readily available and immediately actionable, missed HIV care visits should be incorporated into clinical, programmatic, and policy...

  • AIDS defining diseases in the UK: the impact of PCP prophylaxis and twelve years of change. Porter, Kholoud; Fairley, Christopher K.; Wall, Patrick G.; Evans, Barry G.; Goldberg, David J.; Weerasuriya, Melanie; Noone, Ahilya; Porter, K; Fairley, C K; Wall, P G; Evans, B G; Goldberg, D J; Weerasuriya, M; Noone, A // International Journal of STD & AIDS;Jul1996, Vol. 7 Issue 4, p252 

    We examined all reports of adult AIDS cases made to the 2 national surveillance centres in the UK for changes in AIDS defining conditions between January 1982 and September 1994. Differences and changes among persons diagnosed since January 1988 who had and had not been aware of their HIV...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics