Parathyroid hormone (1-84) plus alendronate was not better than monotherapy with either agent in postmenopausal osteoporosis

May 2004
ACP Journal Club;May/Jun2004, Vol. 140 Issue 3, p62
Academic Journal
This article presents a study to determine the effectiveness of parathyroid hormone (PTH) plus alendronate and monotherapy with either agent for increasing bone mineral density, in postmenopausal women with osteoporosis. 238 postmenopausal women 55 to 85 years of age, who had osteoporosis defined as a T score of less than -2, history of postmenopausal fracture, or maternal history of hip fracture, were taken for the study. Analysis was by intention to treat. Increase in total hip areal bone mineral density (BMD) was greater in the combination group than in the PTH group. Decrease in areal BMD at the distal one third of the radius was greater in the PTH group than in the combination group.


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