TITLE

Estrogen plus progestin reduced risk for fracture in postmenopausal women: COMMENTARY

AUTHOR(S)
Papaioannou, Alexandra
PUB. DATE
May 2004
SOURCE
ACP Journal Club;May/Jun2004, Vol. 140 Issue 3, p61
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The authors, using a global index, confirmed there was no net benefit of estrogen and progestin therapy even in women at high risk for fracture. However, the global index did not include such factors as the risk for dementia and the increase of gynecologic diagnostic procedures because of vaginal bleeding. The risk for probable dementia increased 2-fold in older women allocated to the estrogen and progestin therapy and probably resulted from the increase in vascular dementia. In addition, the number of women requiring diagnostic biopsies increased more than 5-fold among those allocated to combined hormones.
ACCESSION #
13221825

 

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