Estrogen plus progestin reduced risk for fracture in postmenopausal women

May 2004
ACP Journal Club;May/Jun2004, Vol. 140 Issue 3, p61
Academic Journal
This article focuses on the role of estrogen plus progestin to reduce the risk for fracture in postmenopausal women. Analysis was by intention to treat. Fewer women in the hormone therapy group than in the placebo group had a fracture. The effect for total fracture risk remained constant across different subgroups. When treatment effects on other important outcomes were included in a global model, hormone therapy had no net benefit, even in women with high risk for fracture. In a global model assessing treatment effects on all outcomes, hormone therapy had no net benefit.


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