Patterns and predictors of sleep disordered breathing in primary myopathies

Ragette, R.; Mellies, U.; Schwake, C.; Voit, T.; Teschler, H.
August 2002
Thorax;Aug2002, Vol. 57 Issue 8, p724
Academic Journal
Background: Sleep disordered breathing (SDB) is common in neuromuscular diseases but its relationship to respiratory function is poorly defined. A study was undertaken to identify distinct patterns of 5DB, to clarify the relationships between 5DB and lung and respiratory muscle function, and to identify daytime predictors for 5DB at its onset, for 5DB with continuous hypercapnic hypoventilation, and for diurnal respiratory failure. Methods: Upright and supine inspiratory vital capacity (JYC, % predicted), maximal inspiratory muscle pressure (Pimax), respiratory drive (P0.1), respiratory muscle effort (P0.1/Pimax), and arterial blood gas tensions were prospectively compared with polysomnography and capnometry (Ptcco2) in 42 patients with primary myopathies. Results: IVC correlated with respiratory muscle function and gas exchange by day and night. 5DB evolved in three distinct patterns from REM hypopnoeas, to REM hypopnoeas with REM hypoventilation, to REM/non-REM (continuous) hypoventilation, and preceded diurnal respiratory failure. 5DB correlated with IVC and Pimax which yielded highly predictive thresholds for 5DB onset (IVC <60%, Pimax <4.5 kPa), SDB with continuous hypoventilation (IVC <40%, Pimax <4.0 kPa), and SDB with diurnal respiratory failure (IVC <25%, Pimax <3.5 kPa). Conclusion: Progressive ventilatory restriction in neuromuscular diseases correlates with respiratory muscle weakness and results in progressive 5DB which, by pattern and severity, can be predicted from daytime lung and respiratory muscle function.


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