Permanent global amnesia: case report

Bertolucci, Paulo H. F.; Siviero, Marilena O.; Bueno, Orlando F.A.; Okamoto, Ivan H.; Camargo, Candida H.P.; Santos, Ruth F.
April 2004
Clinical & Investigative Medicine;Apr2004, Vol. 27 Issue 2, p101
Academic Journal
Purpose: To present a case of permanent global amnesia related to hippocampal damage. Permanent global amnesia is a very rare condition of unknown etiology; lesions restricted to the hippocampus are uncommon, which hinders investigations of this pattern of memory loss. This case is unusually well documented, as the patient underwent extensive neuropsychological evaluations. Clinical features: A cheerful right-handed, 83-year-old retired electrician was first evaluated in 1990 for progressive difficulty in learning new information and in recalling events over the preceding 3-4 years. Tests over the next 5 years showed that the impairment was confined to episodic declarative memory. New verbal information could be stored only in episodic memory in a restricted manner, limited by short-term memory capacity. A relatively mild retrograde amnesia was detected. Semantic and implicit memory was spared, as were other functions evaluated. The patient's language and executive function were strikingly efficient. Magnetic resonance imaging of the brain showed bilateral atrophy of the hippocampi and amygdalae, ruling out conditions such as tumour growth. A diagnosis of permanent global amnesia was made. In the ensuing years, the retrograde amnesia worsened, but no new deficits were identified. Conclusion: This case, the first with a detailed cognitive examination, is evidence of a relatively pure hippocampal pattern for memory loss in permanent global amnesia.


Related Articles

  • Cortico-subcortical metabolic correlates of olfactory processing in healthy resting subjects. Alessandrini, Marco; Micarelli, Alessandro; Chiaravalloti, Agostino; Candidi, Matteo; Bruno, Ernesto; Di Pietro, Barbara; Schillaci, Orazio; Pagani, Marco // Scientific Reports;6/6/2014, p1 

    A wide network of interconnected areas was previously found in neuroimaging studies involving normal as well as pathological subjects; however literature seems to suffer from a lack of investigation in glucose metabolism behaviour under olfactory condition. Thus, the present work describe for...

  • Aging and the Misinformation Effect: A Neuropsychological Analysis. Roediger, Henry L.; Geraci, Lisa // Journal of Experimental Psychology. Learning, Memory & Cognition;Mar2007, Vol. 33 Issue 2, p321 

    Older adults' susceptibility to misinformation in an eyewitness memory paradigm was examined in two experiments. Experiment I showed that older adults are more susceptible to interfering misinformation than are younger adults on two different tests (old-new recognition and source monitoring)....

  • Development and Standardisation of the Computerised Finger Tapping Test: Comparison with other finger tapping instruments. Christianson, Muriel K.; Leathem, Janet M. // New Zealand Journal of Psychology;Jul2004, Vol. 33 Issue 2, p44 

    The finger-tapping test is a neuropsychological test that assesses motor speed and motor control. The purpose of this study was to obtain normative data for a computerised finger-tapping instrument and to compare it to other traditional finger tapping devices. Eighty-six non-clinical volunteers...

  • NONEQUIVALENCE OF COMPUTERIZED AND PAPER-AND-PENCIL VERSIONS OF TRAIL MAKING TEST. Drapeau, Claire Enea; Bastien-Toniazzo, Mireille; Rous, Cecile; Carlier, Michele // Perceptual & Motor Skills;Jun2007, Vol. 104 Issue 3, p785 

    A computerized version of the Trail Making Test, an adaptation of the classical paper-and-pencil form, was compared with the paper-and-pencil form. The testee must connect targets on the screen with the cursor using the mouse instead of a sheet of paper and a pen. The participants were 68...

  • Normative Data in a Sample of Canadian University Athletes Using ANAM Tests. Hutchison, Michael; Comper, Paul; Mainwaring, Lynda; Richards, Doug // Journal of Clinical Sport Psychology;Dec2012, Vol. 6 Issue 4, p336 

    The baseline / postconcussion neuropsychological (NP) assessment model has been shown to be of clinical value and currently contributes significant information in sport concussion evaluation. Computerized NP batteries are now widely used in elite sport environments and are rapidly becoming more...

  • Play-Based Neuropsychological Assessment of Toddlers. Dykeman, Bruce F. // Journal of Instructional Psychology;Dec2008, Vol. 35 Issue 4, p405 

    Standardized psychological assessment provides a precise yet limited view of the neuropsychological status of preschool toddlers, whose brain functioning is only beginning to develop localized functioning. Yet, referrals for preschool evaluation of these early-age children often request a wide...

  • Cognitive determinants of social functioning after a first ever mild to moderate stroke at vocational age. M Hommel // Journal of Neurology, Neurosurgery & Psychiatry;Aug2009, Vol. 80 Issue 8, p876 

    BACKGROUND AND AIM: Social functioning is impaired in approximately two-thirds of stroke patients of vocational age, even several months after a first ever mild to moderate stroke. The known predictors of social functioning are initial stroke severity, anxiety and depression, and the Mini-Mental...

  • Discriminant analysis of the cognitive performance profile of MS patients differentiates their clinical course. Kraus, Jürgen; Schütze, Cathleen; Brokate, Barbara; Kröger, Beate; Schwendemann, Günther; Hildebrandt, Helmut // Journal of Neurology;Jul2005, Vol. 252 Issue 7, p808 

    Objective To compare the neuropsychological deficits of primary progressive multiple sclerosis with those of relapsing-remitting and secondary progressive multiple sclerosis. Methods Sixty-five patients with different clinical courses of MS were neuropsychologically tested for language,...

  • The latent structure of cognitive symptom exaggeration on the Victoria Symptom Validity Test. Frazier, Thomas W.; Youngstrom, Eric A.; Naugle, Richard I.; Haggerty, Kathryn A.; Busch, Robyn M. // Archives of Clinical Neuropsychology;Feb2007, Vol. 22 Issue 2, p197 

    Abstract: Previous studies have focused on the ability of cognitive symptom validity tests to identify simulated malingering or distinguish between clinical samples of individuals at low or high risk of cognitive symptom exaggeration. However, no published studies have examined the latent...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics