April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA123
Academic Journal
This article presents the case of a 57 year old woman with a history of hypertension and hypercholesterolaemia who was commenced on atorvostatin 10 mg daily. There was no history of excess alcohol consumption. Four weeks later, she presented with jaundice and dark urine. Clinical examination was normal. A liver biopsy showed an acute cholestatic hepatitis. The atorvostatin was withdrawn and the liver function tests improved markedly. The article concludes that clinicians should be aware of the ability of atorvostotin and other statins to cause a cholestatic hepatitis with favourable clinical outcome after drug withdrawal.


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