April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA121
Academic Journal
Globalisation of Western diet or lifestyle will produce 50 percent increase in cancer incidence over the next 20 years. Western diet contains mutagenic N-nitroso compounds (NOC) from red meat and diverse pro-oxidant non-mutogenic agents (PONMA). This article cites a study conducted to test the hypothesis that model NOCs and PONMA have interactive effects upon key events of colonic tumourigenesis. Results of the study suggest that model chemicals, representing genotoxic and non-genotoxic components of Western diet, have adverse interactive effects upon stem cell mutations in mouse colon.


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