TITLE

DENDRITIC CELLS FROM PATIENTS WITH FAMILIAL ADENOMATOUS POLYPOSIS AND COLORECTAL CANCER DISPLAY AN IMMATURE PHENOTYPE--A MECHANISM OF IMMUNE DYSREGULATION PERMISSIVE TO CANCER DEVELOPMENT

PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA120
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This article cites a study to investigate the maturation status of circulating dendritic cell (DC) populations in individuals affected by the pre-malignant condition familial adenomatous polyposis (FAP). Results of the study suggest that the total number of circulating DCs is preserved in FAP patients and individuals with colorectal carcinoma. However, these cells have an immature phenotype with reduced numbers of cells expressing co-stimulatory molecules, and this may be an important mechanism of tumour escape from immunological control.
ACCESSION #
13219282

 

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