April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA119
Academic Journal
This article cites a study to determine the effect of mesalazine (5-ASA) dose on the progression of ulcerative colitis (UC) patients from early grades of dysplasia to advanced neoplasia. Results of the study suggest that high dose 5-ASA at the time of detection of indefinite for dysplasia or low grade dysplasia appears to protect against progression to advanced neoplasia. As subsequent dose appears to be a less important predictor of progression, the effect of 5-ASA is likely to occur early in the colitis-dysplasia-carcinoma sequence.


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