TITLE

THE DESMOPLASTIC REACTION: TRANSFORMING GROWTH FACTOR β-1 SECRETION AND LOCAL RENIN ANGIOTENSIN SYSTEM IN A CARCINOID CELL LINE

PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA118
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The renin angiotensin system (RAS) and transforming growth factor beta-1 (TGFβ-1) are responsible for fibroproliferative changes which can potentially be reduced by pharmacological intervention. Angiotensin II (AngII) may increase TGFβ-1 production and cell proliferation via the Angiotensin II type 1-Receptor (AT1-R). This article cites a study to assess the effect of Losartan, a selective AT1 -R antagonist and Enalaprilat, an ACE inhibitor on their ability to abrogate RAS and hence TGFβ-1 secretion in a human carcinoid cell line.
ACCESSION #
13219274

 

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