April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA118
Academic Journal
The renin angiotensin system (RAS) and transforming growth factor beta-1 (TGFβ-1) are responsible for fibroproliferative changes which can potentially be reduced by pharmacological intervention. Angiotensin II (AngII) may increase TGFβ-1 production and cell proliferation via the Angiotensin II type 1-Receptor (AT1-R). This article cites a study to assess the effect of Losartan, a selective AT1 -R antagonist and Enalaprilat, an ACE inhibitor on their ability to abrogate RAS and hence TGFβ-1 secretion in a human carcinoid cell line.


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