April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA118
Academic Journal
Scientists have previously demonstrated expression of the cholecystokinin 2 (CCK2) receptor in hepatopancreaticobilary cancers and uptake of gastrin analogue peptides by CCK2 expressing tumour cell lines. This article cites a study conducted to test the ability of five DOTA or DTPA coupled pentagastrin analogues to undergo specific uptake by CCK2+ receptor bearing gastric cancer cells. Results of the study suggest that the gastrin analogue peptides can target CCK2 bearing cells and therefore are of potential for targeted therapy of CCK2 receptor positive tumours.


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