TITLE

SPECIFIC TARGETING OF CCK-2 RECEPTOR ON GASTRIC CANCER CELLS WITH PENTAGASTRIN ANALOGUES

PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA118
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Scientists have previously demonstrated expression of the cholecystokinin 2 (CCK2) receptor in hepatopancreaticobilary cancers and uptake of gastrin analogue peptides by CCK2 expressing tumour cell lines. This article cites a study conducted to test the ability of five DOTA or DTPA coupled pentagastrin analogues to undergo specific uptake by CCK2+ receptor bearing gastric cancer cells. Results of the study suggest that the gastrin analogue peptides can target CCK2 bearing cells and therefore are of potential for targeted therapy of CCK2 receptor positive tumours.
ACCESSION #
13219273

 

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