TITLE

LONG TERM CHRONIC HELICOBACTER PYLORI INFECTION UPREGULATES GASTRIC EGFR, C-MET, ADAM 17, AND COX-2 EXPRESSION IN THE MONGOLIAN GERBIL

PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA115
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This article cites a study conducted to examine the effects of long term Helicobacter pylori infection in the Mongolian gerbil on gastric expression of the tyrosine kinase receptors EGFR and c-Met, and of membrane metalloprotease ADAM 17 and COX-2. Results of the study suggests that long term Helicobacter pylori infection in gerbils results in increased gastric expression of EGFR and c-Met receptors which are known to be activated by Helicobacter pylon in vitro. In addition, ADAM 17 and COX-2 transcripts are significantly increased.
ACCESSION #
13219262

 

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