April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA114
Academic Journal
The majority of oesophageal adenocarcinoma arises from Barrett's metaplasia (BM) following a metaplasia-dysplasia-carcinoma sequence. E-cadherin expression is down regulated along this progression, and TNF alpha expression is increased. This article cites a study conducted to investigate the modulation of E-cadherin mRNA by TNF alpha in an ex vivo tissue culture model. Results of the study fail to show a significant modulation of E- cadherin mRNA expression by TNF alpha in an ex vivo model. However, the role of TNF alpha in BM remains elusive and may not be due to alteration of cell to cell adhesion.


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