TITLE

CYCLO-OXYGENASE 2 DOES NOT CONTRIBUTE TO THE DEVELOPMENT OF ACID INDUCED HUMAN VISCERAL PAIN HYPERSENSITIVITY

PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA113
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This article cites a study to determine if Valdecoxib attenuates the development of central sensitization (CS) in human model of oesophageal acidification induced hypersensitivity. Results of the study suggest that constitutive spinal cyclo-oxygenase 2 (COX-2) does not contribute to the initial development of visceral CS. However, COX-2 induction may occur several hours after the onset of inflammation and may therefore contribute to the maintenance of CS. Studies using COX-2 inhibitors to ascertain their role in established CS in visceral hypersensitivity states are therefore warranted.
ACCESSION #
13219254

 

Related Articles

  • Kist Hidatik Ameliyatı Esnasında GeliÅŸen Alerjik Reaksiyon: Olgu Sunumu. İnal, Mehmet Turan; Memiş, Dilek; Akin, Fatih; Sezer, Y. Atakan // Medical Journal of Trakya University / Trakya Universitesi Tip F;2008, Vol. 25 Issue 3, p238 

    Hydatid disease is a parasitic infection caused by echinococcus granulosus and echinococcus alveolaris. This infection is characterized by cyst formation and the liver is the most commonly involved organ. Hydatid cysts can rupture during surgical operation and allergic reaction may occur. In...

  • Novel Approaches for Allergy. Zafra, H.T.; Zacharisen, M.C. // Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy A;Sep2002, Vol. 1 Issue 2, p143 

    The inflammation associated with allergic disease is complex and still not completely understood. With the identification of the various cells and mediators involved in the inflammatory response, new therapies have been and are being developed for use. The central effector cell in allergic...

  • Pathogenic mechanisms: A rational basis for treatment. Howarth, Peter H. // BMJ: British Medical Journal (International Edition);03/07/98, Vol. 316 Issue 7133, p758 

    Discusses the pathogenic mechanism underlying the clinical signs and symptoms of allergic diseases and explains the basis for the choice of differing treatments. Relation of atopy and allergy to disease; Explanations on immunoglobulin E; Mediators of hypersensitivity; Background on inflammatory...

  • AMMONIA EXPOSURE: A COMMON CAUSE FOR SINUSITIS A CASE REPORT AND REVIEW OF THE LITERATURE. Brautbar, Nachman // Toxicology & Industrial Health;Nov/Dec98, Vol. 14 Issue 6, p891 

    Sinuses are a part of the upper respiratory system and sinusitis has been well-defined as an inflammation of the mucous membrane. Sinusitis occurs commonly as a result of allergies, polyps, common cold and environmental pollution. Reports of sinusitis secondary to ammonia exposure, while common...

  • Histamine Injections and Sublingual Drops. Robbins, Albert F. // Latitudes Online;4/2/2009, Vol. 10 Issue 1, p5 

    The article focuses on histamine, a key player in allergic responses. Histamine is found naturally in the human body and claimed as one of the most important mediators produced in allergic reactions and its release triggers allergic symptoms. Neutralization of histamine for allergy treatment and...

  • Considerations in the Prevention of Seasonal Allergic Rhinitis. Barker, Jason; Meletis, Chris // Townsend Letter for Doctors & Patients;May2005, Issue 262, p118 

    Discusses the prevention of seasonal allergic rhinitis. Interest in preventive and anti-inflammatory approach to allergies; Differentiation between true allergic responses and sensitivity; Causes of allergic rhinitis.

  • hives.  // American Heritage Student Science Dictionary;2009, p167 

    The entry provides information on hives. These are itchy welts on the skin that are redder or paler than the surrounding skin. They may result from an allergic reaction, but often the cause is unknown.

  • Genomic Targets in Inflammation and in Allergic Reactions: A Patientoriented Approach. Saito, H. // Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry;Nov2006, Vol. 5 Issue 4, p375 

    Along with advances in the genome sequencing and microarray technologies, many attempts have been made to understand the human diseases systemically. Here, literatures regarding genomic studies on allergic diseases are reviewed, especially by focusing on microarray-based transcriptome studies....

  • Butterfly Rash.  // Arthritis Today;Mar/Apr2006, Vol. 20 Issue 2, p64 

    Presents information on butterfly rash. Description of the rash; Factor that may cause butterfly rash.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics