April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA105
Academic Journal
Thiopurine S-methyl transferase (TPMT} portly predicts the activity and side effects of azathioprine. It is subject to trimodal distribution, with 90% of whites having normal, 10% intermediate, and 0.3% low or absent activity. The similarities in activity between white Europeans and Indlo-Asians is in contrast to the genotype analysis documented in the literature. Block Afro-Caribbeans appear to run a lower level of TPMT activity.


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