April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA105
Academic Journal
The activity of various of the enzymes affecting the metabolism of azathioprine ore affected by allelic polymorphisms. Contrary to - initial reports, ITPA deficiency does not appear to predict toxicity to azathioprine. TPMT deficiency is a stron predictor whereas the MTHFR C677T polymorphism, perhaps throug limiting production of methylated metabolites, appears protective against toxicity.


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