TITLE

PHARMACOGENETIC PROFILING IN AZATHIOPRINE TREATMENT: TPMT, ITPA, AND MTHFR POLYMORPHISMS AND TOXICITY

PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA105
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The activity of various of the enzymes affecting the metabolism of azathioprine ore affected by allelic polymorphisms. Contrary to - initial reports, ITPA deficiency does not appear to predict toxicity to azathioprine. TPMT deficiency is a stron predictor whereas the MTHFR C677T polymorphism, perhaps throug limiting production of methylated metabolites, appears protective against toxicity.
ACCESSION #
13219223

 

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