TITLE

RESPONSES TO KININ AGONISTS IN NON-INFLAMED CAECAL MUCOSA FROM PATIENTS WITH ULCERATIVE COLITIS

PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA104
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Bradykinin B1 receptors are inducible and synthesised de novo under conditions of inflammation or trauma and are likely to be involved in control and maintenance oi inflammatory processes. In vitro study has shown the induction of B1 receptors in damaged tissue. The B1 agonist DAB had no direct effect on the basal short circuit current in human colonic epithetial biopsies. LBK on the other hand resulted in a significant increase in presumed chloride secretion, via an effect on B2 receptors. Pre-exposure to DAB significantly potentiated the responses to LBK.
ACCESSION #
13219219

 

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