April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA103
Academic Journal
Crohn's disease is a chronic inflammatory disorder. Theories as to its causation focus on an over-activation of the immune response. Instead, we show that this disease is actually associated with a failure of acute inflammation. Crohn's disease results from multiple lesions that impair the efficacy of initiating inflammation. CARD15 polymorphisms contribute to, but do not necessarily cause, this phenotype. Persistence of organic and bacterial mailer in the bowel wall consequent to impaired immune clearance probably underlies granuloma formation, and chronic inflammation develops as a secondary phenomenon.


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