TITLE

EFFECT OF NICOTINE ON IL2 AND HUMAN β-DEFENSIN 2 (HBD2) RESPONSES IN AN ORGAN CULTURE MODEL IN IBD

PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA102
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The effects of smoking in inflammatory bowel disease (IBD) are now well established, but the mechanisms by which these occur are unknown, affecting innate or acquired immune responses. Defensins are small molecules produced by epithelial cells, which are thought to have some role in innate defence to micro-organisms. IL2 production is reduced in CD and UC compared with HC, whereas HBD2 is significantly increased in UC. Neither 1L2 nor HBD2 levels significantly changed in response to nicotine alone at any concentration, nor did HBD2 change in response to LPS, with or without nicotine.
ACCESSION #
13219213

 

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