TITLE

TPMT GENOTYPE: IS THIS A COST EFFECTIVE ASSAY FOR PATIENTS ABOUT TO BEGIN AZATHIOPRINE TREATMENT FOR INFLAMMATORY BOWEL DISEASE?

PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA99
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Azathioprine is an extremely useful drug for the treatment of relapsing inflammatory bowel disease. Adverse reactions occur in 15% of which the most dangerous is myelosuppression. This is usually an early event, unpredictable, and seen in 3.2% of patients. Analysis at the literature was undertaken to calculate the expected frequency of side effects and resulting costs of treatment in a theoretical 1000 IBD patient population who were initiated on azathioprine treatment. The use of pretreatment screening For TPMT polymorphisms in IBD patients starting azathioprine treatment represents good value for money.
ACCESSION #
13219202

 

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