April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA98
Academic Journal
L-selectin is shed by activated neutrophils. Smoking adversely affects the natural history of Crohn's disease (CD) although the pathogenic mechanisms involved are unclear. The article investigates whether neutrophil activation, platelet activation, and platelet-leucocyte aggregation are increased in smokers with CD. For this purpose whole blood flow cytometry has been performed on 31 patients. The study revealed that patients with Crohn's disease who smoke have increased neutrophil activation, both in vivo and ex vivo, compared with those who do not smoke.


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