TITLE

DENDRITIC CELLS MAY DRIVE PROINFLAMMATORY T CELL IMMUNE RESPONSES IN CROHN'S DISEASE BY PRODUCTION OF IL-12 AND IL-6

PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA97
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Dendritic cells (DC) are antigen presenting cells that are unique in their ability to activate naive T cells and shape the developing T cell response to be immunogenic or tolerogenic. The article examines that dendritic cells may drive proinflammatory T cell immune responses in crohn's disease (CD) by production of IL-12 and IL-6. The study showed that production of cytokines by colonic DC is altered in active intestinal inflammation. In CD, enhanced production of proinflammatory IL-1 2 by DC may underlie the pathogenic Th 1 response that characterises this disease.
ACCESSION #
13219195

 

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