TITLE

SYNERGISTIC EFFECTS OF SYSTEMIC TREFOIL FACTOR FAMILY 1 AND EPIDERMAL GROWTH FACTOR IN A RAT MODEL OF COLITIS

PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA96
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article investigates the synergistic effects of systemic trefoil factor peptides TFF1 and EGF and epidermal growth factor in a rat model of colitis. The study showed that TFF1-Cys and EGF had synergistic activity in the in vitro assay. Treatment with TFF1 alone reduced colitis score by 22%. Systemic administration TFF1 reduces dextran sulphate sodium induced colitis and Cys is important in this effect, probably by allowing dimerisation. Synergistic effects were seen when co-administered with EGF.
ACCESSION #
13219190

 

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