TITLE

CLINICAL AND FUNCTIONAL SIGNIFICANCE OF VITAMIN D RECEPTOR POLYMORPHISMS IN INFLAMMATORY BOWEL DISEASE

PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA95
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article investigates clinical and functional significance of Vitamin D receptor (VDR) polymorphisms in inflammatory bowel disease. For the study purpose genomic DNA was extracted from 218 inflammatory bowel disease (IBD) patient and also included ulcerative colitis, Crohn's disease (CD) and indeterminate colitis patients. It has been observed that VDR polymorphisms have downstream effects upon target gene expression and clinical significance in IBD. The Fok1 polymorphism has links to colitis associated colorectal neoplasia.
ACCESSION #
13219185

 

Related Articles

  • Confirmation of Multiple Crohn's Disease Susceptibility Loci in a Large Dutch—Belgian Cohort. Weersma, Rinse K.; Stokkers, Pieter C. F.; Cleynen, Isabelle; Wolfkamp, Simone C. S.; Henckaerts, Liesbet; Schreiber, Stefan; Dijkstra, Gerard; Franke, Andre; Nolte, Ilja M.; Rutgeerts, Paul; Wijmenga, Cisca; Vermeire, Séverine // American Journal of Gastroenterology;Mar2009, Vol. 104 Issue 3, p630 

    OBJECTIVES:Inflammatory bowel diseases (IBD)—Crohn's disease (CD) and ulcerative colitis (UC)—are chronic gastrointestinal inflammatory disorders with a complex genetic background. A genome-wide association scan by the Wellcome Trust Case Control Consortium (WTCCC) recently...

  • A Population-Based Case-Control Study of CARD15 and Other Risk Factors in Crohn's Disease and Ulcerative Colitis. Brant, Steven R.; Ming-Hsi Wang; Rawsthorne, Patricia; Sargent, Michael; Datta, Lisa Wu; Nouvet, Franklin; Yin Yao Shugart; Bernstein, Charles N. // American Journal of Gastroenterology;Feb2007, Vol. 102 Issue 2, p313 

    OBJECTIVES: Multiple established Crohn's disease (CD) and ulcerative colitis (UC) risk factors including family history, tobacco use, Jewish ethnicity, urban residency, and CARD15/NOD2 mutations have been evaluated singly and in hospital-based observational studies. The goal of this study was to...

  • Polymorphisms of the TNF gene and the TNF receptor superfamily member 1B gene are associated with susceptibility to ulcerative colitis and Crohn's disease, respectively. Sashio, Hiroko; Tamura, Kazuo; Ito, Reiko; Yamamoto, Yoshihiro; Bamba, Hiroko; Kosaka, Tadashi; Fukui, Shin; Sawada, Koji; Fukuda, Yoshihiro; Tamura, Kazutami; Satomi, Masamichi; Shimoyama, Takashi; Furuyama, Jun-ichi // Immunogenetics;Mar2002, Vol. 53 Issue 12, p1020 

    The importance of tumor necrosis factor (TNF)-alpha and the TNF receptor gene polymorphisms in the etipathogenesis of inflammatory bowel disease (IBD) has not been elucidated. DNA from peripheral blood samples was obtained from 124 patients with Crohn's disease (CD), 106 patients with ulcerative...

  • Hydroxylases as therapeutic targets in inflammatory bowel disease. Cummins, Eoin P.; Doherty, Glen A.; Taylor, Cormac T. // Laboratory Investigation (00236837);Apr2013, Vol. 93 Issue 4, p378 

    Inflammatory bowel disease (IBD) is a common and debilitating clinical disorder comprising ulcerative colitis and Crohn disease. IBD occurs when inappropriate immunological activity in the intestinal mucosa results in epithelial barrier dysfunction leading to exposure of the mucosal immune...

  • Experimental colitis alters expression of 5-HT receptors and transient receptor potential vanilloid 1 leading to visceral hypersensitivity in mice. Matsumoto, Kenjiro; Lo, Mee Wah; Hosoya, Takuji; Tashima, Kimihito; Takayama, Hiromitsu; Murayama, Toshihiko; Horie, Syunji // Laboratory Investigation (00236837);May2012, Vol. 92 Issue 5, p769 

    Abnormalities of primary afferent nerve fibers are strongly associated with the visceral hypersensitivity state in inflammatory bowel disease. Hypersensitivity of afferent fibers occurs during inflammation. Therefore, to gain an insight into the alterations to receptors and channels expressed in...

  • rs224136 on Chromosome 10q21.1 and Variants in PHOX2B, NCF4, and FAM92B Are Not Major Genetic Risk Factors for Susceptibility to Crohn's Disease in the German Population. Glas, Jürgen; Seiderer, Julia; Pasciuto, Giulia; Tillack, Cornelia; Diegelmann, Julia; Pfennig, Simone; Konrad, Astrid; Schmechel, Silke; Wetzke, Martin; Török, Helga-Paula; Stallhofer, Johannes; Jürgens, Matthias; Griga, Thomas; Klein, Wolfram; Epplen, Jörg T.; Schiemann, Uwe; Mussack, Thomas; Lohse, Peter; Göke, Burkhard; Ochsenkühn, Thomas // American Journal of Gastroenterology;Mar2009, Vol. 104 Issue 3, p665 

    OBJECTIVES:Recently, a North American genome-wide association study identified three novel gene variants in PHOX2B, NCF4, and FAM92B as well as one single nucleotide polymorphisms (SNP; rs224136) in the intergenic region on chromosome 10q21.1 as being associated with Crohn's disease (CD)....

  • Genetic Polymorphisms of CYP2D6 Oxidation in Patients with Inflammatory Bowel Disease. Trzcinski, R.; Skretkowicz, J.; Dziki, A.; Rychlik-Sych, M.; Baranska, M. // Digestive Diseases & Sciences;Apr2010, Vol. 55 Issue 4, p1037 

    Inflammatory bowel disease (IBD) consists of ulcerative colitis and Crohn’s disease, both of which are associated with increased colorectal cancer risk. The relationship between genetically determined polymorphic metabolism of exogenous substances by oxidation catalyzed by CYP2D6...

  • Interleukin-4 and interleukin-4 receptor gene polymorphisms in inflammatory bowel diseases. Klein, W; Tromm, A; Griga, T; Fricke, H; Folwaczny, C; Hocke, M; Eitner, K; Marx, M; Duerig, N; Epplen, J T // Genes & Immunity;Aug2001, Vol. 2 Issue 5, p287 

    Imbalances in the regulation of Th1 and Th2 lymphocytes are crucial in inflammatory bowel diseases. Interleukin-4 is secreted by Th2 lymphocytes and downregulates cytokine production from Th I lymphocytes. Functionally relevant polymorphisms have been described in the interleukin-4 and the...

  • The CC chemokine receptor 5 Δ32 mutation is not associated with inflammatory bowel disease (IBD) in NE England. Craggs, A; Welfare, M; Donaldson, P T; Mansfield, J C // Genes & Immunity;Apr2001, Vol. 2 Issue 2, p114 

    Inflammatory bowel disease (IBD) is a group of chronic inflammatory diseases of the gastrointestinal tract of unknown aetiology. Evidence of abnormalities in immune regulation and cytokine production in patients with IBD has led to investigations of various immuno-regulatory genes as potential...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics