TITLE

MICROBIAL MANNAN SUPPRESSES MACROPHAGE KILLING OF BACTERIA: A MECHANISM FOR GRANULOMATOUS INFLAMMATION IN CROHN'S DISEASE

PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA95
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article studies the mechanism for granulomatous inflammation in Crohn's disease in order to investigate that microbial mannan suppresses macrophage killing of bacteria. For the study human peripheral blood mononuclear cells were purified from heparinised venous blood by a one step centrifugation method using PolyrnorphPrep. The presence of S cerevesiae mannan resulted in a 63% reduction in killing of bacteria by monocyte derived macrophages. Results of the study showed that microbial mannan may act as a pathogenic factor in Crohn's disease.
ACCESSION #
13219184

 

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