TITLE

DOSE OF TACROLIMUS REQUIRED TO MAINTAIN THERAPEUTIC LEVELS DECREASES POST LIVER TRANSPLANT IN HEPATITIS C (HCV) RECIPIENTS

PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA93
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article analyzes dose of tacrolimus required to maintain therapeutic levels decreases post liver transplant in hepatitis C (HCV)) recipients. For this purpose tocrolimus dose and level in subpopulations transplanted for HCV infection and alcoholic liver disease (ALD) were compared. It has been observed that the dose of tacrolimus required to maintain a therapeutic level decreased more rapidly over time in HCV patients compared with the ALD patients. The liver injury due to graft reinfection by HCV may lead to decreased hepatic clearance of tacrolimus by HCV transplant recipients.
ACCESSION #
13219180

 

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