TITLE

INCREASED FORMATION OF NITROSOTHIOLS FOLLOWING WARM LIVER ISCHAEMIA REPERFUSION INJURY

PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA92
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article presents a case of increased formation of nitrosothiols following warm liver ischaemia reperfusion injury. Plasma nitrosothiols (RSNOs) may act as a circulating form of nitric oxide (NO) that affects vascular function and platelet aggregation. The increased RSNOs concentration at 5 hours post reperfusion correlates negatively with changes in microcirculation and oxygenation showing that there is marked upregulation of NO synthesis during ischaemia/reperfusion injury. Measurement of RSNOs levels is a better marker of NO activity than nitrite/nitrate plasma levels.
ACCESSION #
13219175

 

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