TITLE

GLYCINE AMELIORATES THE EARLY PHASE OF LIVER WARM ISCHAEMIA REPERFUSION INJURY IN A RABBIT MODEL

PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA92
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article presents a study stating that glycine ameliorates the early phase of liver warm ischaemia reperfusion injury in a rabbit model. Liver ischaemia reperfusion injury (IRI) is a major complication of liver resection and transplantation. Cytokine release by activated Kuppfer cells (KC) plays a central role in this inflammatory response. Glycine a non-essential amino acid may protect against liver injury by inhibition of KC activity. Intravenous glycine administration reduces the hepatic hemodynamic alterations and suppresses TNFα release induced by liver IRI and may provide a novel therapeutic modality.
ACCESSION #
13219174

 

Related Articles

  • Glycine blunts transplantative liver ischemia-reperfusion injury by downregulating interleukin 1 receptor associated kinase-4. LIU, Zuo-jin; YAN, Lu-nan; LI, Shen-wei; YOU, Hai-bo; GONG, Jian-ping // Acta Pharmacologica Sinica;Nov2006, Vol. 27 Issue 11, p1479 

    Aim: To determine whether glycine could downregulate interleukin 1 receptor associated kinase-4 (IRAK-4) expression to interfere with lipopolysaccharides (LPS) signal transduction and blunt transplantative liver ischemia-reperfusion injury (I/RI). Methods: SD rats were randomly divided into two...

  • Graft calcifications and dysfunction following liver transplantation. Tzimas, George N.; Afshar, Mohammad; Chevet, Eric; Emadali, Anouk; Vali, Hojatollah; Metrakos, Peter P. // BMC Surgery;2004, Vol. 4, p9 

    Background: The molecular events, following ischemia and reperfusion (I/R) of the liver during transplantation are largely unknown. There is evidence that apoptotic and necrotic events may take place, and occasionally result in primary graft dysfunction. We herein report two cases, where...

  • Optimal route of administration of mixed endothelin receptor antagonist (TAK-044) in liver transplantation. Tanaka, Wataru; Yamanaka, Naoki; Onishi, Makoto; Ko, Motohiro; Yamanaka, Junichi; Okamoto, Eizo // Journal of Gastroenterology;2000, Vol. 35 Issue 2, p120 

    Abstract: It is well known that endothelin-l(ET-1) is a factor involved in the pathogenesis of ischemiareperfusion injury. This study was undertaken to investigate the optimal route (intravenous vs intraportal) for administering mixed endothelin receptor antagonist (TAK-044) in a liver...

  • Do Contrast Media (Iomeprol, Gadopentetate Dimeglumine) Deteriorate Ischemia/Reperfusion Injury of the Liver? Demir, R.; Banafsche, R.; Melling, N.; Gebhard, M. -M.; Klar, E. // Acta Radiologica;May2007, Vol. 48 Issue 4, p431 

    Background: Hepatic microcirculation is a main determinant of reperfusion injury and graft quality in liver transplantation. One of the important diagnostic procedures to recognize reperfusion failure is contrast-enhanced computed tomography or magnetic resonance imaging. Purpose: To examine the...

  • Oil Red O-assessed macrosteatosis in liver transplant donor biopsies predicts ischemia-reperfusion injury and clinical outcome. Reis, Henning; Peterek, Patricia; Wohlschlaeger, Jeremias; Kaiser, Gernot; Mathe, Zoltan; Juntermanns, Benjamin; Sotiropoulos, Georgios; Beckhove, Ulrich; Canbay, Ali; Wirges, Ulrike; Scherag, Andre; Treckmann, Juergen-Walter; Paul, Andreas; Baba, Hideo // Virchows Archiv;Feb2014, Vol. 464 Issue 2, p165 

    Steatosis in donor livers is an accepted adverse prognostic factor after liver transplantation. While its semiquantitative assessment shows varying reproducibility, it is questioned as a standard method. Additionally, the influence of hepatic steatosis on ischemia/reperfusion injury (I/R injury)...

  • Butyrate protects rats from hepatic ischemia/reperfusion injury. Bin Liu; Zhen-Yu Ma; Gang Wu; Jian-Min Qian // International Journal of Clinical & Experimental Medicine;2015, Vol. 8 Issue 4, p5406 

    Background: Hepatic ischemia/reperfusion (HI/R) injury is a common pathologic process caused by many clinical settings, such as liver resection, liver transplantation, hypovolemic shock and trauma. The use of butyrate, which acts as a four-carbon fatty acid, normally produced by bacterial...

  • Effects of gastrodin on amino acids after cerebral ischemia-reperfusion injury in rat striatum. Xiaodong Bie; Yueqing Chen; Jin Han; Haibin Dai; Haitong Wan; Tongfeng Zhao // Asia Pacific Journal of Clinical Nutrition;2007 Supplement 1, Vol. 16, p305 

    The aim of this study was to explore the effect ofgastrodin on the level of amino acids in the striatum in the rats of cerebral ischemia-reperfusion injury. 30 male SD rats were randomly divided into 3 groups: the group of pseudo-operation (normal control group, NC group), the group of cerebral...

  • I Go by Your Side. Cob, Briceida Cuevas // International Poetry Review;Fall2012, Vol. 38 Issue 2, p21 

    The poem "I Go by Your Side" by Briceida Cuevas Cob and translated from the Mayan/Spanish by Jonathan Harrington is presented. First Line: I am stung again by the arrogant tongues of the women. Last Line: if I go by your side.

  • Glycine reduces renal ischemia-reperfusion injury.  // Kidney;Sep/Oct2002, Vol. 11 Issue 5, p194 

    Presents a summary of the study 'Protective Effect of Glycine on Renal Injury Induced by Ischemia-Reperfusion in Vivo,' by M. Yin, Z. Zhong, H.D. Connor, et al, published in a 2002 issue of the 'American Journal of Physiology and Renal Physiology.'

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics