April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA92
Academic Journal
The article presents a study stating that glycine ameliorates the early phase of liver warm ischaemia reperfusion injury in a rabbit model. Liver ischaemia reperfusion injury (IRI) is a major complication of liver resection and transplantation. Cytokine release by activated Kuppfer cells (KC) plays a central role in this inflammatory response. Glycine a non-essential amino acid may protect against liver injury by inhibition of KC activity. Intravenous glycine administration reduces the hepatic hemodynamic alterations and suppresses TNFα release induced by liver IRI and may provide a novel therapeutic modality.


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