April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA85
Academic Journal
Ketone bodies are the end products of fatty acid oxidation and are primarily synthesised by the liver and exported to be used as fuel by other organs. Very little is known about the metabolism of ketone bodies in cirrhosis. Researchers in this study investigated regional variations in the concentration of acetocetate and β-hydroxybutyrate in metabolically stable cirrhotic patients. This study concludes in cirrhotic patients the liver produced acetoacetate. The brain consumed acetoacetate but not the muscles of the lower limbs. In contrast the liver consumed β-hydroxybutyrate that was produced by the portal drained viscera.


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