April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA81
Academic Journal
Chronic infection with the hepatitis C virus is common. Infection causes slowly progressive liver damage that leads to cirrhosis in 20% of patients after 20 years of infection. To determine the natural history of chronic hepatitis C infection in patients infected for many decodes, researchers studied liver histology in 143 Asian patients infected in early childhood and compared with 239 white people who were infected in adult life. The prevalence of hepatic cirrhosis increased with age in both groups and in elderly Asian patients the majority had cirrhosis.


Related Articles

  • HCV RNA Levels in Serum, Liver, and Peripheral Blood Mononuclear Cells of Chronic Hepatitis C Patients and Their Relationship to Liver Injury. Adinolfi, L. E.; Andreana, A.; Ulili, R.; Zampino, R.; Ragone, E.; Ruggiero, G. // American Journal of Gastroenterology;Nov1998, Vol. 93 Issue 11, p2162 

    Objective: We sought to evaluate the relationship between HCV RNA levels in serum, liver, and peripheral blood mononuclear cells (PBMC) and the degree of liver injury in chronic hepatitis C (CHC) patients. Methods: Thirty-six consecutive CHC patients were included in the study. The liver damage...

  • AST/ALT Ratio Predicts Cirrhosis in Patients With Chronic Hepatitis C Virus Infection. Sheth, Sunil G.; Flamm, Steven L.; Gordon, Fredric D.; Chopra, Sanjiv // American Journal of Gastroenterology;Jan1998, Vol. 93 Issue 1, p44 

    Objective: A liver biopsy is necessary to grade and stage chronic hepatitis C virus (HCV) infection. In a previous study of patients with nonalcoholic liver disease, an aspartate aminotransferase (AST) to alanine aminotransferase (ALT) ratio > 1 suggested cirrhosis. We sought to examine the...

  • Hepatitis C virus E2 protein involve in insulin esistance through an impairment of Akt/PKB and GSK3β signaling in hepatocytes. Ming-Ju Hsieh; Kuang-Ping Lan; Hao-Yu Liu; Xiao-Zong Zhang; Yaw-Feng Lin; Tzy-Yen Chen; Hui-Ling Chiou // BMC Gastroenterology;2012, Vol. 12 Issue 1, p74 

    Background: Hepatitis C virus (HCV) infection may cause liver diseases of various severities ranging from primary acute infection to life-threatening diseases, such as cirrhosis or hepatocellular carcinoma with poor prognosis. According to clinical findings, HCV infection may also lead to some...

  • Growth Differentiation Factor 15 Is Induced by Hepatitis C Virus Infection and Regulates Hepatocellular Carcinoma-Related Genes. Youhui Si; Xiuying Liu; Min Cheng; Maorong Wang; Qiaoling Gong; Yang Yang; Tianyi Wang; Wei Yang // PLoS ONE;2011, Vol. 6 Issue 5, p1 

    Liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC) are commonly induced by chronic hepatitis C virus (HCV) infection. We aimed to identify and characterize the involvement of previously screened cytokine GDF15 in HCV pathogenesis. We examined the GDF15 expression after HCV infection...

  • Role of Non-hepatic Medical Comorbidity and Functional Limitations in Predicting Mortality in Patients with HCV. Natarajan, Yamini; White, Donna; El-Serag, Hashem; Ramsey, David; Richardson, Peter; Kuzniarek, Jill; Shukla, Richa; Tansel, Aylin; Kanwal, Fasiha; White, Donna L; El-Serag, Hashem B // Digestive Diseases & Sciences;Jan2017, Vol. 62 Issue 1, p76 

    Background: Medical comorbidities and functional status limitations are determinants of mortality in many chronic diseases. The extent to which survival in the rapidly aging cohort of patients with HCV is affected by these competing causes of mortality remains unclear.Aim:...

  • Chronic Hepatitis C in Childhood: An 18-Year Experience. Iorio, Raffaele; Giannattasio, Antonietta; Sepe, Angela; Terracciano, Luigi Maria; Vecchione, Raffaella; Vegnente, Angela // Clinical Infectious Diseases;11/15/2005, Vol. 41 Issue 10, p1431 

    Background. The long-term outcome of chronic hepatitis C (CHC) has not been well studied, both for untreated and interferon-treated children. The aim of this study was to evaluate the long-term outcome of disease in a large series of children with CHC. Methods. Clinical, biochemical,...

  • Hepatitis C virus enhances incidence of idiopathic pulmonary fibrosis. Arase, Yasuji; Suzuki, Fumitaka; Suzuki, Yoshiyuki; Akuta, Norio; Kobayashi, Masahiro; Kawamura, Yusuke; Yatsuji, Hiromi; Sezaki, Hitomi; Hosaka, Tetsuya; Hirakawa, Miharu; Saito, Satoshi; Ikeda, Kenji; Kumada, Hiromitsu; Saab, Sammy // World Journal of Gastroenterology;10/14/2008, Vol. 14 Issue 38, p5880 

    AIM: To investigate the cumulative development incidence and predictive factors for idiopathic pulmonary fibrosis in hepatitis C virus (HCV) positive patients. METHODS: We studied 6150 HCV infected patients who were between 40-70 years old (HCV-group). Another 2050 patients with hepatitis B...

  • The Molecular Basis of Drug Resistance against Hepatitis C Virus NS3/4A Protease Inhibitors. Romano, Keith P.; Ali, Akbar; Aydin, Cihan; Soumana, Djade; Özen, Ayşegül; Deveau, Laura M.; Silver, Casey; Hong Cao; Newton, Alicia; Petropoulos, Christos J.; Wei Huang; Schiffer, Celia A. // PLoS Pathogens;Jul2012, Vol. 8 Issue 7, Special section p1 

    Hepatitis C virus (HCV) infects over 170 million people worldwide and is the leading cause of chronic liver diseases, including cirrhosis, liver failure, and liver cancer. Available antiviral therapies cause severe side effects and are effective only for a subset of patients, though treatment...

  • Hepatitis C in renal transplantation. Vosnides, Gregory G. // Kidney International;Sep1997, Vol. 52 Issue 3, p843 

    The article presents two cases that illustrate some of the problems encountered in Hepatitis C Virus (HCV)-infected renal transplant recipients. At the same time, these patients represent two extremes of a wide spectrum of possibilities regarding the outcome of liver disease in this group of...


Read the Article


Sign out of this library

Other Topics