TITLE

EFFECT OF NITRIC OXIDE GENERATED IN THE LUMEN AT GASTROESOPHAGEAL JUNCTION ON THE ADJACENT DIGESTIVE TISSUE IN RATS

AUTHOR(S)
Asanuma, K.; Ikjima, K.; Shimosegawa, T.; Yoshimura, T.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA77
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
In humans, it has been revealed that luminal generation of nitric oxide from dietary nitrate via salivary nitrite is maximal at the gastroesophageal junction (GEJ). The high concentrations of nitric oxide thus generated may contribute to the high incidence of neoplasia at GEJ. The aim of this study is to determine whether high concentrations of nitric oxide generated at GEJ could cause a nitrosative stress on adjacent digestive tissue in rats. Nitric oxide generated in the lumen at GEJ caused localised consumption of glutathione in the adjacent tissue. This nitrosative stress may contribute to high incidence of neoplasia at that site.
ACCESSION #
13219116

 

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