Johns, C. E.; May, F. E. B.; Newton, J. L.
April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA75
Academic Journal
The gut hormone pancreatic polypeptide (PP) is synthesised in the pancreas and nerves of the enteric plexus. It is released in response to food ingestion and contributes to the sensation of satiety. Fasted levels of PP increase with advancing age and it has been suggested that PP may contribute to the "anorexia of ageing." In addition to the increase in fasted PP with advancing age, researchers in this study have shown that ageing is associated with higher PP concentrations throughout the day. Total daytime PP secretion also increases with advancing age.


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