TITLE

LACK OF A SYSTEMIC IMMUNE RESPONSE TO ORAL VACCINATION DOES NOT INDICATE LACK OF MUCOSAL IMMUNITY

AUTHOR(S)
Daley, A. C.; Croft, N.; Randall, R.; Kelly, P.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA72
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Response to oral vaccination is usually assessed by analysis of peripheral blood, but this may not represent mucosal immune responses. Researchers in a study report a comparison of systemic and mucosal immune responses following oral vaccination. Measurement of specific immunoglobulin A responses in whole gut lavage fluid is a sensitive method of assessing the mucosal immune response to oral vaccination. Negative antibody-secreting cell and serological results may not imply that an individual has failed to respond to oral vaccination.
ACCESSION #
13219098

 

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