TITLE

LACK OF A SYSTEMIC IMMUNE RESPONSE TO ORAL VACCINATION DOES NOT INDICATE LACK OF MUCOSAL IMMUNITY

AUTHOR(S)
Daley, A. C.; Croft, N.; Randall, R.; Kelly, P.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA72
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Response to oral vaccination is usually assessed by analysis of peripheral blood, but this may not represent mucosal immune responses. Researchers in a study report a comparison of systemic and mucosal immune responses following oral vaccination. Measurement of specific immunoglobulin A responses in whole gut lavage fluid is a sensitive method of assessing the mucosal immune response to oral vaccination. Negative antibody-secreting cell and serological results may not imply that an individual has failed to respond to oral vaccination.
ACCESSION #
13219098

 

Related Articles

  • Challenges in mucosal vaccines for the control of infectious diseases. Azegami, Tatsuhiko; Yuki, Yoshikazu; Kiyono, Hiroshi // International Immunology;Sep2014, Vol. 26 Issue 9, p517 

    Mucosal vaccines for the control of infectionsThe mucosal surface is the largest route through which pathogens enter the human body. To control the outbreak of mucosal infectious diseases, we must use our knowledge of the mucosal immune system to create vaccines that elicit protective mucosal...

  • Novel M tuberculosis Antigen-Specific T-Cells Are Early Markers of Infection and Disease Progression. Dosanjh, Davinder P. S.; Bakir, Mustafa; Millington, Kerry A.; Soysal, Ahmet; Aslan, Yasemin; Efee, Serpil; Deeks, Jonathan J.; Lalvani, Ajit // PLoS ONE;2011, Vol. 6 Issue 12, p1 

    Background: Mycobacterium tuberculosis Region-of-Difference-1 gene products present opportunities for specific diagnosis of M. tuberculosis infection, yet immune responses to only two gene-products, Early Secretory Antigenic Target-6 (ESAT-6) and Culture Filtrate Protein-10 (CFP-10), have been...

  • Emulsified Nanoparticles Containing Inactivated Influenza Virus and CpG Oligodeoxynucleotides Critically Influences the Host Immune Responses in Mice. Ming-Hsi Huang; Su-Chen Lin; Chia-Hsin Hsiao; Chao, Hsin-Ju; Hung-Ren Yang; Chien-Chun Liao; Po-Wei Chuang; Huang-Pi Wu; Chiung-Yi Huang; Chih-Hsiang Leng; Shih-Jen Liu; Hsin-Wei Chen; Ai-Hsiang Chou; Alan Yung-Chih Hu; Pele Chong // PLoS ONE;2010, Vol. 5 Issue 8, p1 

    Background: Antigen sparing and cross-protective immunity are regarded as crucial in pandemic influenza vaccine development. Both targets can be achieved by adjuvantation strategy to elicit a robust and broadened immune response. We assessed the immunogenicity of an inactivated H5N1 whole-virion...

  • Vaccines in the public eye. Ritvo, Paul; Wilson, Kumanan; Willms, Dennis; Upshur, Ross; Goldman, Adam; Kelvin, David; Rosenthal, Kenneth L.; Rinfret, Aline; Kaul, Rupert; Krahn, Murray // Nature Medicine;Apr2005 Supplement, Vol. 11, p20 

    Preventive vaccines are widely acknowledged as the best hope for protection against infectious pathogens such as avian flu, HIV and SARS. As a result, they have received much recent attention in the media that has exposed some of the challenges involved in optimally using vaccine technology.

  • SINTIMVAS: A NOVEL VACCINATION STRATEGY FOR FUTURE VACCINES. González, E.; Romeu, B.; Del Campo, J.; Acevedo, R.; Lastre, M.; Zayas, C.; Cuello, M.; Cabrera, O.; Balboa, J.; Perez, O. // Revista VacciMonitor (Vacunología y Temas Afines);2010 Supplement 1, Vol. 19, p20 

    Vaccination is considered to be the most cost-effective strategy for controlling infectious diseases. Epidemiologically targeted implementation of vaccines has diminished morbidity and mortality from many infectious diseases that previously were scourges and economic burdens, in spite of the...

  • A predictive model for the level of sIgA based on IgG levels following the oral administration of antigens expressed in Sacchromyces cerevisiae. Sung Jae Shin; Seung Won Shin; Eun Jin Choi; Deog Yong Lee; Jeong Min Ahn; Moon Sik Yang; Yong Suk Jang; Han Sang Yoo // Journal of Veterinary Science;2005, Vol. 6 Issue 4, p305 

    Oral vaccination may be the most efficient way of inducing an immune response at the remote mucosal site through the common mucosal immune network. Antigen- specific secretory IgA (sIgA) is the major immunoglobulin type generally detected in the secretions of experimental animals following an...

  • CHAPTER 1: Getting Immunized.  // Mayo Clinic Family Health Book;2003, p1 

    This chapter provides information on immunization. Immunization, another term for vaccination, is the best line of defense against diseases such as measles, mumps, tetanus, hepatitis and polio. Vaccines are prepared in several different ways. For each type, the goal is to stimulate an immune...

  • Rational design of HIV vaccines and microbicides: report of the EUROPRISE annual conference 2011. Ruffin, Nicolas; Borggren, Marie; Euler, Zelda; Fiorino, Fabio; Grupping, Katrijn; Halleng�rd, David; Javed, Aneele; Mendonca, Kevin; Pollard, Charlotte; Reinhart, David; Saba, Elisa; Sheik-Khalil, Enas; Sk�ld, Sk�ld; Ziglio, Serena; Scarlatti, Gabriella; Gotch, Frances; Wahren, Britta; Shattock, Robin J. // Journal of Translational Medicine;2012, Vol. 10 Issue 1, p144 

    Europrise is a Network of Excellence supported by the European Commission within the 6th Framework programme from 2007 to 2012. The Network has involved over 50 institutions from 13 European countries together with 3 industrial partners and 6 African countries. The Network encompasses an...

  • revaccination.  // Taber's Cyclopedic Medical Dictionary;2005, p1904 

    A definition of the term "revaccination" is presented. It refers to an inoculation against a disease to sustain a passive immune response against a potentially infectious organism.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics