Spencer, H. L.; Daniels, I.; Long, R. G.; Murray, I. A.
April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA72
Academic Journal
The article presents a study conducted to confirm, increased plasma NOx levels in patients with untreated celiac disease. Plasma NOx falls rapidly after starting a gluten free diet (GFD) in celiac disease and is related to histological grade initially. It continues to fall for at least 6 months. Inducible nitric oxide synthase is expressed in the small intestine of patients with celiac disease. This produces increased plasma concentration of nitric oxide end products (NOx) most marked in those ingesting gluten. The rate of change in NOx over time following the introduction of a GFD and its relationship to histology and celiac serology is unknown.


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