TITLE

A ROLE FOR TNF-α IN THE REGULATION OF SMALL BOWEL IRON ABSORPTION

AUTHOR(S)
Sharma, N.; Tselepis, C.; Butterworth, J.; Cooper, B. T.; Iqbal, T. H.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA71
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Iron, an essential nutrient, is absorbed in the proximal small bowel via divalent metal transporter 1 (DMT-1). DMT-1 expression is tightly regulated by the body's iron requirements. The article presents a study conducted to demonstrate a modulation of DMT-1 expression by TNF-&b.alpha;, on effect that may have important clinical implications. In celiac disease the increase in DMT-1 could, in part, be due to small bowel inflammation and may show a protective mechanism against iron deficiency. Finally, treatments aimed at blocking the effect of TNF-&b.alpha; could have potentially deleterious effects on small bowel iron absorption.
ACCESSION #
13219095

 

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