TITLE

THE RAPID REPRESSION OF DMT-1 BY THE HEPATIC ANTIMICROBIAL PEPTIDE HEPCIDIN

AUTHOR(S)
Sharma, N.; Tselepis, C.; Butterworth, J.; Cooper, B. T.; Iqbal, T. H.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA71
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article presents a study that provides evidence that hepcidin can cause direct repression of the principal enterocyte iron absorption protein, divalent metal transporter 1 (DMT-1). Studies suggest that the hepatic antimicrobial peptide hepcidin is the key regulator of small bowel iron absorption. It appears to be induced in response to high body iron stores and the proinflammatory cytokine IL-6. It causes a rapid inhibition of small bowel iron absorption although the enterocyte target for its action is unknown. Caco-2 cells, an established model for the study of enterocyte function, were challenged for up to 24 hours with varying concentrations of hepcidin peptide.
ACCESSION #
13219094

 

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