Yap, L. M.; Lottaz, D.; Ahmad, T.; Zhang, L.; van Heel, D.; McGovern, D.; Negoro, K.; Sterchi, E.; Sanderson, I.; Welsh, K.; Jewell, D. P.
April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA71
Academic Journal
The article presents a study conducted to identify MEP1A polymorphisms and test for association with celiac disease. MEP1A is located at 6p11-12 in proximity to the HLA region, which has been widely replicated as a susceptibility locus for celiac disease. Mutations were detected by directly sequencing deoxyribonucleic acid samples from 12 celiac, 6 NOD2 negative CD, and 6 UC patients. Association with disease was tested in a case control study in 192 celiac patients and 372 healthy controls. The study found no significant associations between the meprin &b.alpha; gene locus and celiac disease.


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