TITLE

SCREENING OF RELATIVES OF PATIENTS WITH COELIAC DISEASE

AUTHOR(S)
Fraser, J. S.; Dewar, D. H.; Johnson, M.; Ellis, H. J.; Bjarnason, I.; Ciclitira, P. J.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA70
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
First degree relatives of individuals with celiac disease are thought to have a 10% chance of also being affected. This higher prevalence might suggest that screening relatives of celiac patients would be beneficial in identifying undiagnosed cases of celiac disease. A percentage of celiac patients have either immunoglobulin A (IgA) deficiency or have negative IgA antibody tests. Therefore an IgA quantification or additional immunoglobulin G (IgG) based antibody test is required when screening. The authors recommend an algorithm for screening of first degree relatives of patients with celiac disease. Screening for celiac disease in such individuals should include at least one IgG based screening test. Second degree relatives would not appear to have an increased prevalence of celiac disease.
ACCESSION #
13219089

 

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