Nankivell, P. C.; Boxall, S. J.; Taylor, A. J.; Linehan, J. D.
April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA70
Academic Journal
The article presents a study conducted to investigate whether patients with a raised tissue transglutaminase (tTG) need to have small bowel biopsies to confirm the diagnosis of celiac disease (CD). The introduction of an immunoassay measuring antibodies against tTG has changed the investigation of patients with potential CD and is widely used by both general practitioners and gastroenterologists. Before this anti-endomysial antibodies were measured as a screening test. This test was hard to reproduce and required patients to undergo gastroscopy and small bowel biopsies to confirm the diagnosis.


Related Articles

  • Screening for Celiac Disease in a North American Population: Sequential Serology and Gastrointestinal Symptoms. Katz, Kent D.; Rashtak, Shahrooz; Lahr, Brian D.; Melton, L. Joseph; Krause, Patricia K.; Maggi, Kristine; Talley, Nicholas J.; Murray, Joseph A. // American Journal of Gastroenterology;Jul2011, Vol. 106 Issue 7, p1333 

    OBJECTIVES:The prevalence of diagnosed celiac disease is <1 in 2,000 in the United States, but screening studies undertaken in European and other populations have revealed a much higher prevalence. The objective of this study was to determine the prevalence of celiac disease and the utility of...

  • Editorial: Celiac Disease in Turkey: Lessons From the Fertile Crescent. Catassi, Carlo // American Journal of Gastroenterology;Aug2011, Vol. 106 Issue 8, p1518 

    Abstract: Celiac disease (CD) is as frequent in Turkey as in Western countries. This finding challenges old theories hypothesizing a selective effect of agriculture spreading on the predisposition to develop CD. Despite the availability of reliable serological tests, e.g., the...

  • Missing endomysial and reticulin binding of coeliac antibodies in transglutaminase 2 knockout tissues. Korponay-Szabó, I.R.; Laurila, K.; Szondy, Z.; Halttunen, T.; Szalai, Z.; Dahlbom, I.; Rantala, I.; Kovács, J.B.; Fésüs, L.; Máki, M. // Gut;Feb2003, Vol. 52 Issue 2, p199 

    Background: Autoantibodies against transglutaminase 2 (TG2) are thought to be responsible for the endomysial (EMA), reticulin (ARA), and jejunal antibody (JEA) tissue binding of serum samples from coeliac patients but the exclusive role of TG2 in these staining patterns has not yet been...

  • The role of antitissue transglutaminase assay for the daignosis and monitoring of coeliac disease: a French—Italian muticentre study. Tonutti, E.; Visentini, D.; Bizzara, N.; Caradonna, M.; Cerni, L.; Villalta, D.; Tozzoli, R. // Journal of Clinical Pathology;May2003, Vol. 56 Issue 5, p389 

    Aims: Tissue transglutaminase (tTG) was recently identified as the major autoantigen in coeliac disease. The aim of this multicentre study was to evaluate the impact of a new immunoenzymatic assay for the detection of IgA anti-tGT antibodies. Methods: Seventy four Italian and French clinical...

  • Anti-tissue transglutaminase antibodies from coeliac patients inhibit transglutaminase activity both in vitro and in situ. Esposito, C.; Paparo, F.; Caputo, I.; Rossi, M.; Maglio, M.; Sblattero, D.; Not, T.; Porta, R.; Auricchio, S.; Marzari, R.; Troncone, R. // Gut;Aug2002, Vol. 51 Issue 2, p177 

    Background and aims: Coeliac disease (CD) is a multifactorial disorder which has an autoimmune component characterised by the occurrence of disease specific autoreactive antibodies against the enzyme tissue transglutaminase (tTG). The aim of this study was to investigate whether binding of...

  • In vivo targeting of intestinal and extraintestinal transglutaminase 2 by coeliac autoantibodies. Korponay-Szabó, I. R.; Halttunen, I.; Szalai, Z.; Laurila, K.; Király, R.; Kovács, J. B.; Fésüs, L.; Möki, M. // Gut;May2004, Vol. 53 Issue 5, p641 

    Background: IgA class serum autoantibodies against type 2 (tissue) transglutaminase (TG2) bind to both intestinal and extraintestinal normal tissue sections in vitro, eliciting endomysial, reticulin, and jelunal antibody reactions. It is not known whether similar binding also occurs in coeliac...

  • Celiac disease in Williams-Beuren syndrome. Şimşek-Kiper, Pelin Özlem; Şahin, Yavuz; Arslan, Umut; Alanay, Yasemin; Boduroğlu, Koray; Orhan, Diclehan; Özen, Hasan; Ütine, Gülen Eda // Turkish Journal of Pediatrics;Mar/Apr2014, Vol. 56 Issue 2, p154 

    Celiac disease was previously reported to be frequent among individuals with Williams-Beuren syndrome; however, this suggestion was not investigated further. The present study was conducted to estimate the prevalence of celiac disease in a group of Turkish individuals with Williams-Beuren...

  • Majority of Children With Type 1 Diabetes Produce and Deposit Anti-Tissue Transglutaminase Antibodies in the Small Intestine. Maglio, Mariantonia; Florian, Fiorella; Vecchiet, Monica; Auricchio, Renata; Paparo, Francesco; Spadaro, Raffaella; Zanzi, Delia; Rapacciuolo, Luciano; Franzese, Adriana; Sblattero, Daniele; Marzari, Roberto; Troncone, Riccardo // Diabetes;Jul2009, Vol. 58 Issue 7, p1578 

    OBJECTIVE--Anti-tissue transglutaminase (TG2) antibodies are the serological marker of celiac disease. Given the close association between celiac disease and type 1 diabetes, we investigated the production and deposition of anti-TG2 antibodies in the jejunal mucosa of type 1 diabetic children....

  • Intestinal biopsy is not always required to diagnose celiac disease: a retrospective analysis of combined antibody tests. Bürgin-Wolff, Annemarie; Mauro, Buser; Faruk, Hadziselimovic // BMC Gastroenterology;2013, Vol. 13 Issue 1, p1 

    Background: The objective of this study was to compare celiac disease (CD)- specific antibody tests to determine if they could replace jejunal biopsy in patients with a high pretest probability of CD. Methods: This retrospective study included sera from 149 CD patients and 119 controls, all with...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics