Nisar, P. J.; Acheson, A. G.; Scholofield, J. H.; Wilson, V. G.
April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA69
Academic Journal
The article presents a study conducted to examine the effect of brimonidine, a selective &b.alpha;2-adrenoceptor agonist used for treating glaucoma, on myogenic tone and neurogenic responses in isolated sheep internal anal sphincter (lAS). Topical application of phenylephrine, a selective &b.alpha;2-adrenoceptor agonist increases anal sphincter pressure in subjects with passive fecal incontinence, but its potential use is limited by local side effects. Using a validated model, strips of sheep lAS were prepared for isometric tension recording. Each preparation was electrically stimulated at 1 Hz and 10 Hz for 30 seconds in the absence and presence of brimonidine.


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