TITLE

DETECTION OF MICROMETASTASES IN LYMPH NODES USING REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION FOR CYTOKERATIN 20: ARE WE UNDERSTAGING RECTAL CANCER?

AUTHOR(S)
Wijesuriy, S. R. E.; Kuruppuarachchi, K. G. R.; Deen, K. I.; Weerasinghe, A.; Ramesh, R.; Hewavisenthi, J.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA66
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article presents a study of the detection of micrometastases in lymph nodes using reverse transcription polymerase chain reaction for cytokeratin 20. Postoperative adjuvant chemotherapy in rectal cancer is determined by the presence of metastases in lymph nodes. Detection of lymph node metastases is routinely performed by light microscopy. Conventional histology may not detect all metastases especially following neoadjuvant therapy. Cytokeratin 20 is a cytokeratin known to be specific to colonic epithelium which may help detection of rectal cancer metastases in lymph nodes.
ACCESSION #
13219071

 

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