TITLE

RECTAL BRUSH BIOPSY -- EXPLORATION OF ITS ROLE AS AN ALTERNATE SOURCE OF COLORECTAL TISSUE FOR BOWEL RESEARCH

AUTHOR(S)
Reddy, R.; Janssens, L.; Kelly, S. B.; Welfare, M.; Williams, L.; Mathers, J. C.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA66
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article presents a study of rectal brush biopsy. An exploration of its role as an alternate source of colorectal tissue for bowel research is presented. Epigenetic changes including aberrant gene promoter methylation of colorectal cancer related genes have been documented before the development of neoplasia. These changes are currently detected in colonic mucosal biopsy samples obtained from sigmoidoscopy/colonoscopy. Rectal brush biopsy is a safe alternative, relatively cheap and patient friendly procedure of obtaining cells from the colorectum. Sufficient DNA can be extracted from rectal brushes for assessment of gene methylation.
ACCESSION #
13219070

 

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