TITLE

DNA DERIVED FROM PROBIOTIC BACTERIA MODULATES HUMAN DENDRITIC CELL PHENOTYPE AND FUNCTION

AUTHOR(S)
Lammers, K. M.; Hart, A. L.; Brigidi, P.; Vitali, B.; Rizzello, F.; Gionchetti, P.; Campieri, M.; Kamm, M. A.; Knight, S. C.; Stogg, A. J.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA65
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article presents a study stating that DNA derived from probiotic bacteria modulates human dendritic cell phenotype and function. Unmethylated CpG motifs, predominantly present in bacterial DNA, can be immunostimulatory via toll-like receptor (TLR)-9. Commensal bacteria play a role in maintaining immune homeostasis in the gut. Dendritic cells (DC) are modulated by microbial products, including DNA, to shape a developing T cell response. Therefore, the study determined the effects of DNA derived from probiotic bifidobacteria, lactobacilli, and Streptococcus thermophilus on DC.
ACCESSION #
13219068

 

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