Lala, S.; Turton, D.; Keshav, S.
April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA65
Academic Journal
The article presents a study of lysozyme and secretory phospholipase A2 expression in necrotizing enterocolitis (NEC). NEC is a severe inflammatory gastrointestinal disorder predominantly affecting neonates. A leading theory postulates that NEC develops when aberrant colonisation by enteric bacteria triggers an intestinal inflammatory response. Paneth cells secrete an array of antimicrobial peptides, such as the α-defensins, secretory phospholipase A2 type IIA, and lysozyme in response to bacteria and bacterial products.


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