TITLE

EFFECTS OF GLUCOCORTICOIDS ON EXPRESSION OF P-GLYCOPROTEIN AND GLUCOCORTICOID RECEPTOR IN THE INTESTINAL EPITHELIUM

AUTHOR(S)
Moodie, F.; Lyons, V.; Satsangi, J.; Seckl, J. R.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA65
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article studies the effects of glucocorticoids on expression of p-glycoprotein and glucocorticoid receptor in the intestinal epithelium. Glucocorticoids are the primary drug treatment in inflammatory bowel disease. However, at least 20 percent of patients are steroid resistant. P-glycoprotein encoded by the multidrug resistance gene 1a and 1b in rodents and MDR1 in humans is expressed on the surface of the intestinal epithelium and is known to actively exclude dexamethasone and other synthetic steroids from cells.
ACCESSION #
13219066

 

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