TITLE

EXPRESSION OF TOLL-LIKE RECEPTORS BY INTESTINAL EPITHELIAL CELLS IN AN IN VITRO M CELL MODEL

AUTHOR(S)
Butler, M.; Winstanley, S.; Lombardi, G.; Lechler, R.; Playford, R.; Ghosh, S.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA64
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article presents an investigation of toll-like receptors by intestinal epithelial cells in an in vitro M cell model. A number of groups have reported the differentiation of intestinal epithelial cell lines to cells with M cell characteristics (enhanced transcytosis, altered morphology) following co-culture with immune cell subsets. M cells are the main route by which gut antigens access the mucosal immune system and are thus ideally situated to detect pathogenic microorganisms. To investigate this possibility, it has been analysed that Caco-2 monolayers for their expression of Toll-like receptor mRNA transcripts following conditioning by immune cell subsets.
ACCESSION #
13219065

 

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